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ClinVar has an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice web site are a comparatively typical explanation for aberrant splicing (PMID: 17576681, 9536098). Algorithms developed to forecast the impact of sequence alterations on RNA splicing suggest this variant may create or bolster a splice web page. In summary, the obtainable evidence is presently insufficient to ascertain the purpose of the variant in ailment. As a result, it's been labeled like a Variant of Uncertain Importance. (considerably less)

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This column contains additional information supporting the classification, which includes citations, the comment on classification, and comprehensive evidence furnished as observations from the variant because of the submitter.

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These citations are determined by LitVar utilizing the rs quantity, so They might incorporate citations for multiple variant at this site. Please assessment the LitVar benefits meticulously on your variant of curiosity. Document final updated May perhaps twelve, 2024 

Stars represent the review position, or the level of assessment supporting the submitted (SCV) record. This value is calculated by NCBI based on information in the submitter.

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